Journal of Pathology and Translational Medicine

Sanghui Park

5 Articles

Histologically confirmed distant metastatic urothelial carcinoma from the urinary bladder: a retrospective review of one institution’s 20-year experience: Youngeun Yoo, Junghye Lee, Heae Surng Park, Min-Sun Cho, Sun Hee Sung, Sanghui Park, Euno Choi; J Pathol Transl Med. 2021;55(2):94-101. Published online December 3, 2020; DOI: https://doi.org/10.4132/jptm.2020.10.19

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Background
Urothelial carcinoma (UC) accounts for roughly 90% of bladder cancer, and has a high propensity for diverse differentiation. Recently, certain histologic variants of UC have been recognized to be associated with unfavorable clinical outcomes. Several UC studies have also suggested that tumor budding is a poor prognostic marker. Distant metastasis of UC after radical cystectomy is not uncommon. However, these metastatic lesions are not routinely confirmed with histology.
Methods
We investigated the histopathologic features of 13 cases of UC with biopsy-proven distant metastases, with a special emphasis on histologic variants and tumor budding.
Results
Lymph nodes (6/13, 46%) were the most common metastatic sites, followed by the lung (4/13, 31%), liver (4/13, 31%), and the adrenal gland (2/13, 15%). The histologic variants including squamous (n=1), micropapillary (n=4), and plasmacytoid (n=1) variants in five cases of UC. Most histologic variants (4/5, 80%) of primary UCs appeared in the metastatic lesions. In contrast, high-grade tumor budding was detected in six cases (46%), including one case of non-muscle invasive UC. Our study demonstrates that histologic variants are not uncommonly detected in distant metastatic UCs. Most histologic variants seen in primary UCs persist in the distant metastatic lesions. In addition, high-grade tumor budding, which occurs frequently in primary tumors, may contribute to the development of distant metastasis.
Conclusions
Therefore, assessing the presence or absence of histologic variants and tumor budding in UCs of the urinary bladder, even in non-muscle invasive UCs, may be useful to predict distant metastasis.

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Do Histology and Primary Tumor Location Influence Metastatic Patterns in Bladder Cancer?
Hyung Kyu Park
Current Oncology.2023; 30(10): 9078. CrossRef

Double cocktail immunostains with high molecular weight cytokeratin and GATA-3: useful stain to discriminate in situ involvement of prostatic ducts or acini from stromal invasion by urothelial carcinoma in the prostate: Junghye Lee, Youngeun Yoo, Sanghui Park, Min-Sun Cho, Sun Hee Sung, Jae Y. Ro; J Pathol Transl Med. 2020;54(2):146-153. Published online February 10, 2020; DOI: https://doi.org/10.4132/jptm.2019.11.12

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Abstract PDF

Background
Distinguishing prostatic stromal invasion (PSI) by urothelial carcinoma (UC) from in situ UC involving prostatic ducts or acini with no stromal invasion (in situ involvement) may be challenging on hematoxylin and eosin stained sections. However, the distinction between them is important because cases with PSI show worse prognosis. This study was performed to assess the utility of double cocktail immunostains with high molecular weight cytokeratin (HMWCK) and GATA-3 to discriminate PSI by UC from in situ UC involvement of prostatic ducts or acini in the prostate.
Methods
Among 117 radical cystoprostatectomy specimens for bladder UCs, 25 cases showed secondary involvement of bladder UC in prostatic ducts/acini only or associated stromal invasion and of these 25 cases, seven cases revealed equivocal PSI. In these seven cases with equivocal PSI, HMWCK, and GATA-3 double immunohistochemical stains were performed to identify whether this cocktail stain is useful to identify the stromal invasion.
Results
In all cases, basal cells of prostate glands showed strong cytoplasmic staining for HMWCK and UC cells showed strong nuclear staining for GATA-3. In cases with stromal invasion of UC, GATA-3-positive tumor cells in the prostatic stroma without surrounding HMWCK-positive basal cells were highlighted and easily recognized. Among seven equivocal cases, two cases showed PSI and five in situ UC in the prostate. In two cases, the original diagnoses were revised.
Conclusions
Our study suggested that HMWCK and GATA-3 double stains could be utilized as an adjunct method in the distinction between PSI by UC from in situ UC involving prostatic ducts or acini.

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Aberrant expression of GATA3 in metastatic adenocarcinoma of the prostate: an important pitfall
João Lobo, Nazario P Tenace, Sofia Cañete‐Portillo, Isa Carneiro, Rui Henrique, Roberta Lucianò, Lara R Harik, Cristina Magi‐Galluzzi
Histopathology.2024; 84(3): 507. CrossRef
Utility of D2-40, Cytokeratin 5/6, and High–Molecular-weight Cytokeratin (Clone 34βE12) in Distinguishing Intraductal Spread of Urothelial Carcinoma From Prostatic Stromal Invasion
Oleksii A. Iakymenko, Laurence M. Briski, Katiana S. Delma, Merce Jorda, Oleksandr N. Kryvenko
American Journal of Surgical Pathology.2022; 46(4): 454. CrossRef

Tailgut Cyst in a Neonate: A Case Report: Ji Hyen Lee, Yun Suk Lee, So Yeon Shim, Su Jin Cho, Eun Ae Park, Soon Sup Chung, Sanghui Park; J Pathol Transl Med. 2016;50(4):315-317. Published online April 6, 2016; DOI: https://doi.org/10.4132/jptm.2015.11.27

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Epidemiology, diagnostic approach and therapeutic management of tailgut cysts: A systematic review
Aikaterini Mastoraki, Ilias Giannakodimos, Karmia Panagiotou, Maximos Frountzas, Dimosthenis Chrysikos, Stylianos Kykalos, Georgios E. Theodoropoulos, Dimitrios Schizas
International Journal of Clinical Practice.2021;[Epub] CrossRef
Pediatric congenital buttock sinus tract:10-year experience in a single institution
Kai Wang, Chunhui Peng, Wenbo Pang, Dayong Wang, Tingchong Zhang, Zengmeng Wang, Dongyang Wu, Yajun Chen
BMC Pediatrics.2019;[Epub] CrossRef

Cytomegalovirus-Associated Intussusception with Florid Vascular Proliferation in an Infant: Heejung Park, Sanghui Park, Young Ju Hong, Sun Wha Lee, Min-Sun Cho; J Pathol Transl Med. 2015;49(3):270-273. Published online May 15, 2015; DOI: https://doi.org/10.4132/jptm.2015.04.01

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Severe Postnatal Cytomegalovirus Enterocolitis in Immunocompetent Term Infants Requiring Total Parenteral Nutrition
Annaleise R. Howard-Jones, Giancarlo H. Cristerna-Tarrasa, Rabia Khan, Michael Stormon, Susan Arbuckle, Philip N. Britton
JPGN Reports.2021; 2(3): e110. CrossRef
Retrospective multicenter matched case–control study on the risk factors for intussusception in infants less than 1 year of age with a special focus on rotavirus vaccines – the German Intussusception Study
Doris Oberle, Marcus Hoffelner, Jutta Pavel, Dirk Mentzer, Immanuel Barth, Ursula Drechsel-Bäuerle, Brigitte Keller-Stanislawski
Human Vaccines & Immunotherapeutics.2020; 16(10): 2481. CrossRef
Ebola Virus Causes Intestinal Tract Architectural Disruption and Bacterial Invasion in Non-Human Primates
Ronald Reisler, Xiankun Zeng, Christopher Schellhase, Jeremy Bearss, Travis Warren, John Trefry, George Christopher, Mark Kortepeter, Sina Bavari, Anthony Cardile
Viruses.2018; 10(10): 513. CrossRef

Cervical Lymphadenopathy Mimicking Angioimmunoblastic T-Cell Lymphoma after Dapsone-Induced Hypersensitivity Syndrome: Min Young Rim, Junshik Hong, Inku Yo, Hyeonsu Park, Dong Hae Chung, Jeong Yeal Ahn, Sanghui Park, Jinny Park, Yun Soo Kim, Jae Hoon Lee; Korean J Pathol. 2012;46(6):606-610. Published online December 26, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.6.606

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Abstract PDF

A 36-year-old woman presented with erythematous confluent macules on her whole body with fever and chills associated with jaundice after 8 months of dapsone therapy. Her symptoms had developed progressively, and a physical examination revealed bilateral cervical lymphadenopathy and splenomegaly. Excisional biopsy of a cervical lymph node showed effacement of the normal architecture with atypical lymphoid hyperplasia and proliferation of high endothelial venules compatible with angioimmunoblastic T-cell lymphoma. However, it was assumed that the cervical lymphadenopathy was a clinical manifestation of a systemic hypersensitivity reaction because her clinical course was reminiscent of dapsone-induced hypersensitivity syndrome. A liver biopsy revealed drug-induced hepatitis with no evidence of lymphomatous involvement. Intravenous glucocorticoid was immediately initiated and her symptoms and clinical disease dramatically improved. The authors present an unusual case of cervical lymphadenopathy mimicking angioimmunoblastic T-cell lymphoma as an adverse reaction to dapsone.

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Morphologic Spectrum of Lymphadenopathy in Drug Reaction With Eosinophilia and Systemic Symptoms Syndrome
Hui-Chun Chen, Ren Ching Wang, Huey-Pin Tsai, L. Jeffrey Medeiros, Kung-Chao Chang
Archives of Pathology & Laboratory Medicine.2022; 146(9): 1084. CrossRef
Antibacterial antibiotic-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a literature review
Shiva Sharifzadeh, Amir Hooshang Mohammadpour, Ashraf Tavanaee, Sepideh Elyasi
European Journal of Clinical Pharmacology.2021; 77(3): 275. CrossRef
Drug-Induced Hypersensitivity Syndrome: A Clinical, Radiologic, and Histologic Mimic of Lymphoma
Faaria Gowani, Bradley Gehrs, Teresa Scordino
Case Reports in Hematology.2018; 2018: 1. CrossRef
In vitro testing for diagnosis of idiosyncratic adverse drug reactions: Implications for pathophysiology
Abdelbaset A. Elzagallaai, Michael J. Rieder
British Journal of Clinical Pharmacology.2015; 80(4): 889. CrossRef
Dapsone-induced drug reaction with eosinophilia and systemic symptoms syndrome, misdiagnosed as lymphoma
Bomi Shin, So Young Park, Sun-Young Yoon, Eun-Hye Shin, Young-Joo Yang, Hyung-Jin Cho, Il-Young Jang, Dong-Uk Kang, Tae-Bum Kim, You Sook Cho, Hee-Bom Moon, Hyouk-Soo Kwon
Allergy, Asthma & Respiratory Disease.2013; 1(4): 400. CrossRef
T-cell lymphoma presenting as drug rash with eosinophilia and systemic symptoms syndrome
Mi-Ae Kim, Hye-Soo Yoo, Sun Hyuk Hwang, Yoo Seob Shin, Dong-Ho Nahm, Hae-Sim Park
Allergy Asthma & Respiratory Disease.2013; 1(3): 280. CrossRef

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